Promethazine has an elimination 50 %-lifetime of 10-14 hours, with excretion of metabolites appearing from the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites showing within the urine.
Check with your healthcare provider if you have any questions on this facts. Prior to deciding to consider PROMETHAZINE VC WITH CODEINE ORAL SOLUTION, explain to your healthcare provider about your entire health-related situations, including should you: Possess a drug addiction
Diligently measure the dose utilizing a Exclusive measuring unit/spoon. Will not use a household spoon as you might not get the correct dose.
To decreased your threat, your medical doctor ought to have you go ahead and take smallest dose that works, and get it for the shortest achievable time. See also Tips on how to Use segment To learn more about addiction.
The codeine and promethazine in Promethazine with Codeine Oral Solution could increase the frequency of seizures in individuals with seizure Conditions, and should improve the chance of seizures taking place in other medical settings linked with seizures.
This medication may perhaps cause you to more delicate towards the Sunshine. Limit your time and efforts inside the Solar. Avoid tanning booths and sunlamps. Use sunscreen and don protective clothing when outdoor. Inform your health care provider immediately if you receive sunburned or have pores and skin blisters/redness.
In the event the response to an opioid antagonist is suboptimal or only brief in mother nature, administer additional antagonist as directed by the solution’s prescribing information. The respiratory depressant effects of promethazine usually are not reversed by opioid antagonists, such as naloxone.
The dosage of Promethazine with Codeine Oral Option should not be improved if cough fails to respond; an unresponsive cough need to be reevaluated for feasible underlying pathology.
Although the chance of habit in any particular person is mysterious, it may happen in people correctly prescribed Promethazine VC with Codeine Oral Solution. Habit can arise at proposed dosages and if the drug is misused or abused. Dangers are improved in people with a private or spouse and children history of compound click here abuse (like drug or alcohol abuse or dependancy) or mental health issues (eg., significant melancholy).
Promethazine with Codeine Oral Answer might cause intense hypotension which include orthostatic hypotension and syncope in ambulatory sufferers. There is certainly elevated hazard in clients whose means to maintain hypertension has currently been compromised by a lessened blood quantity or concurrent administration of selected CNS depressant medications (e.
Codeine is contraindicated in youngsters younger than twelve a long time of age and in kids of any age who're undergoing tonsillectomy and/or adenoidectomy. Prevent use in adolescents 12 to 18 a long time of age who have other threat aspects which could boost their sensitivity towards the respiratory depressant impact of codeine.
This medication can dry up and thicken mucus as part of your lungs, which makes it harder to breathe and clear your lungs. To help reduce this result, drink a lot of fluids Unless of course otherwise directed by your doctor.
The danger for extreme breathing problems is bigger when You begin this medication, or if you're taking the wrong dose or choose additional of the medication than prescribed. Using this medication with alcohol or other prescription drugs that might cause drowsiness or respiration problems may possibly result in pretty critical Unwanted side effects, together with Loss of life. Also, other drugs can have an affect on the removing of this product or service out of your body, which can have an impact on how it really works.
It's soluble in drinking water and freely soluble in Alcoholic beverages. The molecular bodyweight is 320.88. Its molecular system is C17H20N2S•HCl, and it's the subsequent chemical structure.